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K&A Synthesizer Requirements – FAQ

⚙️ System & Hardware Requirements

Q: What are the minimum PC requirements to run the synthesizer software?
A:

  • Operating System: Windows 10 or 11 (64-bit)

  • Processor: Intel i5 or better

  • RAM: 8 GB minimum (16 GB recommended)

  • Storage: 256 GB SSD or higher

  • Ports:

    • Ethernet port required with static IP configuration (see below)

    • USB port(s) for driver installation or peripherals

  • Display: 1920x1080 minimum resolution

  • Admin privileges required for installation

🌐 Networking Requirements

Q: What network settings are required to operate the synthesizer?
A:

  • The synthesizer communicates via a direct Ethernet connection.

  • The connected PC must be configured with a static IP address: 192.168.1.1.

  • No DHCP or internet access is required for instrument operation.

Q: Can I connect the synthesizer to my company network?
A: Yes. However IP conflicts might arise and cause communication issues.

🧪 Reagent & Consumable Requirements

Q: What type of amidites are supported?
A: The synthesizer supports standard DNA, RNA, and modified amidites. For RNA, ensure your amidites are fully protected (TOM, TBDMS, or UltraMild formats). Contact our support for validated suppliers and protocols.

Q: What column types are compatible?
A: Supports standard Luer fittings. Supports syringe style columns with certain adapters.

🔌 Power & Pneumatics

Q: What are the electrical power requirements?
A:

  • 4 outlets required:
    • Instrument
    • Compressor
    • Computer 
    • Monitor

  • Voltage: 100–240V AC

  • Frequency: 50/60 Hz

  • Power: 300–500W depending on model

  • Surge protection strongly recommended

Q: What are the gas/vacuum requirements?
A:

  • Inert Gas (Nitrogen or Argon):

    • Pressure: 60–80 psi regulated

    • Purity: ≥99.99%

Q: Can I use house air or gas?
A: Yes but it must maintain specifications for purity as stated above

💻 Connectivity & Software

Q: Is an internet connection required?
A: Not for daily operation. However, internet access is recommended for software updates and remote support

Q: What ports or drivers are needed for PC connectivity?
A:

  • USB 2.0 

  • Ethernet port

  • Admin rights required for software installation

💻 Legacy Software Compatibility

Q: Can I use older versions of the software on modern PCs?
A:

  • Some legacy software versions requires 32-bit versions of Windows.

  • These versions may also depend on Serial (COM) port connections, not Ethernet.

  • If you're running legacy software, we recommend using a dedicated older PC or virtual machine configured appropriately.

Q: Can legacy software run on 64-bit Windows?
A: In most cases, no. Some older programs are not compatible with 64-bit operating systems. 

🧼 Lab Environment & Safety

Q: What are the environmental requirements for the instrument?
A:

  • Temperature: 18–25°C (64–77°F)

  • Humidity: <60% non-condensing

  • Clean, well-ventilated lab area

  • Fume hood or dedicated exhaust recommended for handling deblock and waste fumes

Q: Is a waste trap  needed?
A: Yes. A chemical waste carboy is required to safely capture acidic and volatile fumes from synthesis byproducts.